Publications

See on Google Scholar and ORCID.

Published

John Lees, Marco Galardini, Stephen Bentley, Jeffrey Weiser, Jukka Corander. pyseer: a comprehensive tool for microbial pangenome-wide association studies. Bioinformatics doi:10.1093/bioinformatics/bty539 (2018).

John Lees, Michelle Kendall, Julian Parkhill, Caroline Colijn, Stephen Bentley, Simon Harris. Evaluation of phylogenetic reconstruction methods using bacterial whole genomes: a simulation based study. Wellcome Open Research 3:33 doi:10.12688/wellcomeopenres.14265.2 (2018).

John Lees, Nicholas Croucher, David Goldblatt, François Nosten, Julian Parkhill, Claudia Turner, Paul Turner, Stephen Bentley. Genome-wide identification of lineage and locus specific variation associated with pneumococcal carriage duration. eLife 6:e26255 doi:10.7554/eLife.26255 (2017).

John Lees, Philip Kremer, Ana Manso, Nicholas Croucher, Bart Ferwerda, Mercedes Valls Serón, Marco Oggioni, Julian Parkhill, Matthijs Brouwer, Arie van der Ende, Diederik van de Beek, Stephen Bentley. Large scale genomic analysis shows no evidence for pathogen adaptation between the blood and cerebrospinal fluid niches during bacterial meningitis. Microbial Genomics 3:1–12 doi:10.1099/mgen.0.000103 (2017).

John Lees, Matthijs Brouwer, Arie van der Ende, Julian Parkhill, Diederik van de Beek, Stephen Bentley. Within-Host Sampling of a Natural Population Shows Signs of Selection on Pde1 during Bacterial Meningitis. Infect Immun 85:e01061–16 doi:10.1128/IAI.01061-16 (2017).

John Lees, Minna Vehkala, Niko Välimäki, Simon Harris, Claire Chewapreecha, Nicholas Croucher, Pekka Marttinen, Mark Davies, Andrew Steer, Steven Tong, Antti Honkela, Julian Parkhill, Stephen Bentley, Jukka Corander. Sequence element enrichment analysis to determine the genetic basis of bacterial phenotypes. Nat Commun 7:12797 doi:10.1038/ncomms12797 (2016).

Gerry Tonkin-Hill, John Lees, Stephen Bentley, Simon Frost, and Jukka Corander. 2018. RhierBAPS: An R Implementation of the Population Clustering Algorithm hierBAPS. Wellcome Open Research 3 doi:10.12688/wellcomeopenres.14694.1 (2018).

Santeri Puranen, Maiju Pesonen, Johan Pensar, Ying Ying Xu, John Lees, Stephen Bentley, Nicholas  Croucher, and Jukka Corander. SuperDCA for Genome-Wide Epistasis Analysis. Microbial Genomics doi:10.1099/mgen.0.000184 (2018).

Philip Kremer, John Lees, Merel Koopmans, Bart Ferwerda, Agaath Arends, Monique Feller, Kim Schipper, Mercedes Valls Seron, Arie van der Ende, Matthijs Brouwer, Diederik van de Beek, Stephen Bentley. Benzalkonium tolerance genes and outcome in Listeria monocytogenes meningitis. Clinical Microbiology and Infection doi:10.1016/j.cmi.2016.12.008 (2016).

Ula Khatib, Diederik van de Beek, John Lees, Matthijs Brouwer. Adults with suspected central nervous system infection: A prospective study of diagnostic accuracy. J. Infect. doi:10.1016/j.jinf.2016.09.007 (2016).

Sophia David, Christophe Rusniok, Massimo Mentasti, Laura Gomez-Valero, Simon Harris, Pierre Lechat, John Lees, Christophe Ginevra, Philippe Glaser, Laurence Ma, Christiane Bouchier, Anthony Underwood, Sophie Jarraud, Timothy Harrison, Julian Parkhill, Carmen Buchrieser. Multiple major disease-associated clones of Legionella pneumophila have emerged recently and independently. Genome Res. 26, 1555–1564 doi: (2016).

Reviews

John Lees, Gerry Tonkin-Hill and Stephen Bentley. Stronger Together. Nat Rev Micro 15:9. doi: 10.1038/nrmicro.2017.95 (2017).

John Lees, and Stephen Bentley. Bacterial GWAS: not just gilding the lily. Nat Rev Micro 14:406 doi: 10.1038/nrmicro.2016.82 (2016).

John Lees, and Rebecca Gladstone. R–M systems go on the offensive. Nat Rev Micro 13:3 doi: 10.1038/nrmicro3435 (2015).

Amy Cain and John Lees. Using genomics to combat infectious diseases on a global scale. Genome Biol. 16, 250 doi: 10.1186/s13059-015-0822-y (2015).

Pre-publication

John Lees, Simon Harris, Gerry Tonkin-Hill, Rebecca Gladstone, Stephanie Lo, Jeffrey Weiser, Jukka Corander, Stephen Bentley, and Nicholas Croucher. 2018. “Fast and Flexible Bacterial Genomic Epidemiology with PopPUNK.” bioRxiv. doi:10.1101/360917 (2018)

John Lees, Bart Ferwerda, Philip Kremer, Nicole Wheeler, Mercedes Valls Serón, Nicholas Croucher, …  Jeffrey Barrett, Stephen Bentley, Diederik van de Beek. Joint Sequencing of Human and Pathogen Genomes Reveals the Genetics of Pneumococcal Meningitis. bioRxiv. doi:10.1101/386078 (2018)