# Impute your whole genome from 23andme data

Contents

23andme is a service which types 602352 sites on your chromosomal DNA and your mtDNA. It is possible, by comparing to a reference panel in which all sites have been typed, to impute (fill in statistically) the missing sites and thus get an ’estimation’ of your whole genome.

The piece of software impute2 written by B. N. Howie, P. Donnelly, and J. Marchini gives good accuracy when using the 1000 Genome Project as a reference. However, there is some difficulty in providing the data in the right input format, using all the correct options and interpreting the output from this piece of software.

EDIT: As pointed out by lassefolkersen in the comments, this has now been nicely implemented at impute.me

I have written a tool to allow people with a small amount computational experience (but not necessarily any biological/bioinformatics knowledge) to run this tool on their 23andme data to get their whole genome output, which can be found at my github: https://github.com/johnlees/23andme-impute

To use this tool, you will need to do the following steps:

1. Download your ‘raw data’ from the 23andme site. This is a file named something like genome_name_full